Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Сhronic autoimmune hepatitis is an urgent problem of modern medicine due to the widespread prevalence among all diseases (more than 25%) and difficulty its diagnosis lack reliable serological tests for detection. The purpose this work was study possibility method monochrome analysis nanoparticles in noninvasive detection AIG develop algorithm rapid chronic by saliva. goal solved performing a number tasks: development diagnostic determine severity pathophysiological orientation homeostatic shifts patients with verified using samples oropharyngeal flushes (saliva), as well calculation specificity sensitivity test. Materials methods: studies were conducted at Center European Oriental Medicine from 2019 2022, 14 examined. It found that most typical saliva spectra liver damage characterized three-modality predominance light scattering on particles super-large diameter (over 1000 nm) significant increase contribution small medium hydrodynamic size, which statistically (p<0.001) when conducting comparative practically healthy individuals general somatic non-autoimmune genesis. indicators 95%, - 93%. Conclusions: results scientific research developed use laser spectroscopy hepatitis, timely diagnosis, therapeutic measures will be maximally effective aimed preventing complications systemic manifestations disease, nanoparticles.